Liane B. Russell is a renowned geneticist. Born in Vienna, Austria, she and her family managed to flee the country after its annexation by Nazi Germany. After moving to the United States, Russell became interested in biological research. In 1947, she and her husband, William L. Russell, moved to Oak Ridge. In this interview, Russell explains her experiments on the effects of radiation at Oak Ridge National Laboratory’s “Mouse House,” including the discovery that the Y chromosome is sex-determining. She describes her work with the environmental movement and the efforts of Tennessee Citizens for Wilderness Planning, which she co-founded. She also recalls winning the Enrico Fermi Award from the Department of Energy and a visit to communist East Germany in the 1980s.