James L. Smith is a physicist at Los Alamos National Laboratory (LANL). In this interview, Smith recalls his more than forty-year career at LANL. He describes some of the history of the Manhattan Project and LANL’s innovative work during the war through today, including work on the human genome, computing, and radiation detection. He emphasizes the importance of having multidisciplinary national laboratories to produce pioneering innovations and scientific discoveries. Smith also recalls his friendship with Edward Teller, who he was assigned to teach about superconductivity, and other Manhattan Project scientists including Nicholas Metropolis. He discusses Teller’s relationship with Oppenheimer and other scientists.